It varies. You will have excellent 4G/LTE coverage in Panama City, Colon, and the main towns in Bocas del Toro (Bocas Town).
- Bocas del Toro: You will have a signal in the main town, but it will be intermittent or non-existent on remote beaches (like Starfish Beach) or in the jungle.
- San Blas Islands (Guna Yala): These islands are extremely remote. There is little to no mobile signal. An eSIM is for the mainland, not for this autonomous region.